Have questions? We have answers. Select a topic below to read up on treating relapsing MS with VUMERITY® (diroximel fumarate).


What should I do before I start taking VUMERITY?

First, you and your healthcare provider should have an open conversation about your medical history. Take a closer look into which conditions are especially important to discuss.

Your healthcare provider should also check your white blood cell count:

  • before you start VUMERITY
  • 6 months after starting treatment
  • every 6-12 months thereafter, and as they feel necessary

How should I take VUMERITY?

During your first week, you’ll take the starter dose of one pill (231 mg) twice a day. After your first week, you’ll take the regular dose of two pills (462 mg) twice a day.

It’s important to take VUMERITY exactly as prescribed by your healthcare provider. Swallow VUMERITY whole. Do not crush, chew, or sprinkle contents on food.

If you take too much VUMERITY, call your healthcare provider or go to the nearest hospital emergency room right away. Read more about VUMERITY dosing.

What should I know about taking VUMERITY with food?

If you eat at the same time you take your VUMERITY pills, you should not take your VUMERITY with a high-fat, high-calorie meal or snack. Eating a high-fat, high-calorie meal or snack at the time you take your VUMERITY pills could reduce the amount of the active ingredient that your body absorbs. The meal or snack should contain no more than 700 calories and no more than 30 grams of fat. Find snack or meal inspiration here.

What should I know about VUMERITY and alcohol?

If you’re taking VUMERITY, you do not have to stop drinking alcohol altogether.

But you should not drink alcohol at the same time you take your VUMERITY pills. That's because drinking alcohol at the same time you take your VUMERITY pills could reduce the amount of the active ingredient that your body absorbs.

I missed a dose of VUMERITY. How can I remember to take it?

Taking VUMERITY exactly as prescribed by your healthcare provider gives you the best chance of getting its full benefits. Recommended dosing for VUMERITY is two pills taken twice a day. We have several tips that could help you stay on track with treatment.

Can I take VUMERITY if I’m pregnant?

You should always talk to your healthcare provider before taking VUMERITY if you are pregnant, interested in becoming pregnant, breastfeeding, or planning to breastfeed. That’s because it isn’t known how taking VUMERITY would affect an unborn baby or if it passes into your breast milk.

Have the COVID-19 vaccines been studied in people taking VUMERITY?

No, the COVID-19 vaccines have not yet been studied in people treating their relapsing MS with disease-modifying therapies, such as VUMERITY.

Can I receive a COVID-19 vaccine?

You may be eligible to receive a COVID-19 vaccine. As with any important medical decision, we strongly urge you to discuss your options with your healthcare provider. They can best advise you on which COVID-19 vaccine is right for you. The National MS Society is also a reliable resource for current vaccine-related information.

Do I need to stop or delay my treatment to take a COVID-19 vaccine?

The decision to stop, pause, or delay medical treatment—VUMERITY or otherwise—should always be a conversation with your doctor.

The National MS Society has provided guidance around continuing to treat with VUMERITY. Be sure to ask your healthcare provider for advice, as they know your treatment plan best.

Side effects

Does VUMERITY have serious side effects?

Some serious side effects of VUMERITY include:

  • allergic reactions
  • PML (a rare brain infection that usually leads to death or severe disability over a period of weeks or months)
  • herpes zoster infections (shingles), including central nervous system infections
  • other serious infections
  • decreases in your white blood cell count
  • liver problems

What are the most common side effects of VUMERITY?

Flushing and stomach problems are the most common side effects of dimethyl fumarate. Flushing symptoms are usually described as redness, itching, or rash. Stomach symptoms include nausea, vomiting, diarrhea, stomach pain, or indigestion.

Learn more about common side effects of VUMERITY and how they tended to decrease over time in clinical trials.

What should I do if I experience common side effects?

If you're experiencing any of the common side effects of VUMERITY, talk to your healthcare provider about trying the tips below.

Tips for flushing

Taking a non-coated aspirin (up to 325 mg) half an hour before taking VUMERITY may help with flushing. Taking VUMERITY with food (avoid high-fat, high-calorie meal or snack) may also help.

Tips for stomach problems

Over-the-counter medicines, like antacids, may help relieve stomach problems. Read more about tips for handling the most common side effects.

How long do common side effects last?

In clinical trials, common side effects tended to happen earlier in treatment and usually decreased over time. Keep in mind that everyone is different and may react differently to the same medication.


How effective is VUMERITY?

VUMERITY is a pill that may help in three ways:

How can I tell if VUMERITY is working?

Talking to your healthcare provider about the results of your magnetic resonance imaging (MRI) scan of your brain could help with the management of your relapsing multiple sclerosis (MS). Brain lesions revealed on an MRI scan may help your healthcare provider determine how well your treatment is working.

How does VUMERITY work?

During times of inflammation, the body produces toxins that can cause oxidative stress. When this oxidative stress builds up, it can damage cells or even destroy them in different parts of the body, including the central nervous system (CNS). Inflammation within the CNS can also cause oxidative stress, and oxidative stress may trigger more inflammation.

One way the body combats inflammation is through the Nrf2 pathway. This pathway is a complex communication system that defends cells against oxidative stress.

Although we don’t know exactly how VUMERITY works against relapsing MS, researchers have learned that the active form* of VUMERITY leads to activation of the Nrf2 pathway, which may help defend against oxidative stress. Talk to your doctor to learn more about your treatment options.

*Once it’s processed in the body.

Finding support

What kind of support does VUMERITY offer?

Biogen, the maker of VUMERITY, is here to support you. Get tips, tools, and personalized assistance for your relapsing MS from Biogen Support Services, including:

  • One-on-one phone support from our Support Coordinators
  • Free access by phone to Nurse Educators 24/7
  • A variety of financial and insurance support services, and our Biogen Copay Program (if you’re eligible)
  • Information about VUMERITY treatment and support services
  • Support available in Spanish

We encourage you to learn more about the support that comes with VUMERITY. Remember, your healthcare provider is your first source of information.

What can I do if my insurance doesn't cover VUMERITY?

Biogen, the maker of VUMERITY, offers financial and insurance support through Biogen Support Services. This includes speaking with Support Coordinators, who may be able to help you navigate insurance coverage, the Biogen Copay Program and Free Drug Program,* and support finding assistance through charitable organizations.

*For eligible patients only.

How can I find out if I’m eligible for the Biogen Copay Program?

The Biogen Copay Program has no income requirements and no enrollment time limit for those who qualify. You can find out if you’re eligible by calling 1-800-456-2255. A Support Coordinator will answer your questions and help you enroll if you’re eligible for the Biogen Copay Program.

There is an annual cap on the amount of assistance that patients can receive over a one-year period. Federal and state laws and other factors may prevent or otherwise restrict eligibility. People covered by Medicare, Medicaid, the VA/DoD, or any other federal plans are not eligible to enroll. You are eligible to enroll in the Biogen Copay Program for as long as it is offered and you are treated with VUMERITY.

How can a Nurse Educator help me?

Nurse Educators are registered nurses, and many are MS-certified. They understand the challenges you may be facing and are ready to support you throughout your time on VUMERITY. They’re available to:

  • Answer questions or provide information 24/7 related to your relapsing MS and VUMERITY
  • Provide ongoing phone support, including information on how to take your medication and help manage common side effects
  • Review instructions from your healthcare provider and connect you with available resources

Although Nurse Educators can be a great resource for you, it’s important to remember that your healthcare provider is always your best source of information.

Contact Nurse Educators 24/7 at 1-800-456-2255. Hablamos español.

What resources are available for care partners?

Caring for someone with relapsing MS can be both fulfilling and challenging. It’s important to have a support system you can count on. Below are some resources you may find helpful along the way:

Caregiver Action Network: A great source for free articles, videos, advice, and resources.

CareGiving.com: Join a community that understands. Chat, get tips, and learn from stories written by other caregivers.