What else should I consider when exploring VUMERITY?

Deciding on the right treatment option for your relapsing MS is a big decision. In addition to a medicine’s effectiveness, there may be some other points worth discussing with your healthcare provider. Below are some things you may want to consider when deciding if VUMERITY® (diroximel fumarate) is the right fit for you.

VUMERITY and certain medications


When taken 30 minutes before, aspirin did not affect the effectiveness of dimethyl fumarate. Your healthcare provider may recommend taking a non-coated aspirin (up to 325 mg) to help with flushing.

Oral contraceptive—norelgestromin and ethinyl estradiol

In a study using dimethyl fumarate, there were no relevant effects on the combination oral contraceptive norelgestromin and ethinyl estradiol. No other studies have been done with oral contraceptives containing other progestogens.

Dimethyl fumarate

Do not take VUMERITY while treating with dimethyl fumarate.

Taking VUMERITY with alcohol

Do not drink alcohol at the same time you take your VUMERITY dose. Get more information on VUMERITY and alcohol.

VUMERITY and several
non-live vaccines

A study of adults (aged 27-55) with relapsing MS investigated what happens when people receive several non-live vaccines while treating with dimethyl fumarate.

The study found that dimethyl fumarate did not weaken the body’s response to three non-live vaccines:

  • Tetanus-diphtheria toxoid
  • Pneumococcal
  • Meningococcal

The safety and effectiveness of getting any other vaccine while taking dimethyl fumarate or VUMERITY have not been studied, and we do not know VUMERITY’s impact on vaccine effectiveness. As with any medical decision, it’s best to talk to your healthcare provider if you’re considering any type of vaccination.