Have questions? We have answers. Select a topic below to read up on treating relapsing MS with VUMERITY® (diroximel fumarate).


What should I do before I start taking VUMERITY?

First, you and your healthcare provider should have an open conversation about your medical history. Take a closer look into which conditions are especially important to discuss.

Your healthcare provider should also check your white blood cell count:

  • before you start VUMERITY
  • 6 months after starting treatment
  • every 6-12 months thereafter, and as they feel necessary

How should I take VUMERITY?

During your first week, you’ll take the starter dose of one pill (231 mg) twice a day. After your first week, you’ll take the regular dose of two pills (462 mg) twice a day.

It’s important to take VUMERITY exactly as prescribed by your healthcare provider. Swallow VUMERITY whole. Do not crush, chew, or sprinkle contents on food.

If you take too much VUMERITY, call your healthcare provider or go to the nearest hospital emergency room right away. Read more about VUMERITY dosing.

What should I know about taking VUMERITY with food?

If you take VUMERITY with food, avoid taking it with a high-fat, high-calorie meal or snack. Your meal or snack should contain no more than 700 calories and no more than 30 g of fat. Do not drink alcohol at the same time as you take a VUMERITY dose. Get a closer look at how to take VUMERITY.

I missed a dose of VUMERITY. How can I remember to take it?

Taking VUMERITY exactly as prescribed by your healthcare provider gives you the best chance of getting its full benefits. Recommended dosing for VUMERITY is two pills taken twice a day. We have several tips that could help you stay on track with treatment.

Can I take VUMERITY if I’m pregnant?

You should always talk to your healthcare provider before taking VUMERITY if you are pregnant, interested in becoming pregnant, breastfeeding, or planning to breastfeed. That’s because it isn’t known how taking VUMERITY would affect an unborn baby or if it passes into your breast milk.

Side effects

Does VUMERITY have serious side effects?

Some serious side effects of VUMERITY include:

  • allergic reactions
  • PML (a rare brain infection that usually leads to death or severe disability over a period of weeks or months)
  • herpes zoster infections (shingles), including central nervous system infections
  • other serious infections
  • decreases in your white blood cell count
  • liver problems

What are the most common side effects of VUMERITY?

Flushing and stomach problems are the most common side effects of dimethyl fumarate, which is a medicine with the same active metabolite as VUMERITY. Flushing symptoms are usually described as redness, itching, or rash. Stomach symptoms include nausea, vomiting, diarrhea, stomach pain, or indigestion.

Learn more about common side effects of VUMERITY and how they tended to decrease over time in clinical trials.

What should I do if I experience common side effects?

If you're experiencing any of the common side effects of VUMERITY, talk to your healthcare provider about trying the tips below.

Tips for flushing

Taking a non-coated aspirin (up to 325 mg) half an hour before taking VUMERITY may help with flushing. Taking VUMERITY with food (avoid high-fat, high-calorie meal or snack) may also help.

Tips for stomach problems

Over-the-counter medicines, like antacids, may help relieve stomach problems. Read more about tips for handling the most common side effects.

How long do common side effects last?

In clinical trials, common side effects tended to happen earlier in treatment and usually decreased over time. Keep in mind that everyone is different and may react differently to the same medication.

Should I worry about PML?

PML is a very rare but serious brain infection caused by the JC virus. In most people, the JC virus is controlled by the immune system. However, sometimes when someone is taking treatments that affect the immune system (like most treatments for relapsing MS), existing JC virus may activate and cause PML.


How effective is VUMERITY?

In clinical studies, dimethyl fumarate—which has the same active metabolite as VUMERITY—was shown to:

What is a metabolite?

A metabolite is part of the medication that remains after the drug has been processed (or metabolized) in the body. VUMERITY has the same active metabolite as dimethyl fumarate.

How can I tell if VUMERITY is working?

Talking to your healthcare provider about the results of your magnetic resonance imaging (MRI) scan of your brain could help with the management of your relapsing multiple sclerosis (MS). Brain lesions revealed on an MRI scan may help your healthcare provider determine how well your treatment is working.

How does VUMERITY work?

It is unknown exactly how VUMERITY works in the body, but researchers have discovered what it does in the cells.

  • Oxidative stress

    During inflammation, the body produces toxins that can cause oxidative stress on the cells. When this stress builds up, it can damage or even destroy healthy cells in different parts of the body, including the central nervous system (CNS)

  • Nrf2 pathway

    One way the body reacts to oxidative stress is through a pathway called Nrf2, short for nuclear factor (erythroid-derived 2)-like 2. This pathway is an important part of a complex communication system involved in the body's response to oxidative stress

  • Dimethyl fumarate

    Researchers have learned that dimethyl fumarate leads to activation of the Nrf2 pathway in our cells. Much about how VUMERITY works in the body remains unknown, but talking with your doctor can help you learn more about your treatment options

Finding support

What kind of support does VUMERITY offer?

Biogen, the maker of VUMERITY, is here to support you. Get tips, tools, and personalized assistance for your relapsing MS from Biogen Support Services, including:

  • One-on-one phone support from our Support Coordinators
  • Free access by phone to Nurse Educators 24/7
  • A variety of financial and insurance support services, and our Biogen Copay Program (if you’re eligible)
  • Information about VUMERITY treatment and support services
  • Support available in Spanish

We encourage you to learn more about the support that comes with VUMERITY. Remember, your healthcare provider is your first source of information.

What can I do if my insurance doesn't cover VUMERITY?

Biogen, the maker of VUMERITY, offers financial and insurance support through Biogen Support Services. This includes speaking with Support Coordinators, who may be able to help you navigate insurance coverage, the Biogen Copay Program and Free Drug Program,* and support finding assistance through charitable organizations.

*For eligible patients only.

How can I find out if I’m eligible for the Biogen Copay Program?

The Biogen Copay Program has no income requirements and no enrollment time limit for those who qualify. You can find out if you’re eligible by calling 1-800-456-2255. A Support Coordinator will answer your questions and help you enroll if you’re eligible for the Biogen Copay Program.

Copay details and eligibility include:

  • Depending on your income or, in some cases, if your medication is obtained from an out-of-network provider, there may be an annual cap that limits the amount of assistance that you can receive over one year
  • Federal and state laws and other factors may prevent or otherwise restrict eligibility. People covered by Medicare, Medicaid, the VA/DoD, or any other federal plans are not eligible to enroll
  • You are eligible to enroll in the Biogen Copay Program for as long as it is offered and you are treated with VUMERITY

How can a Nurse Educator help me?

All of our Nurse Educators are registered nurses trained to provide you and your care partner with additional support along your relapsing MS journey. This includes answering questions about relapsing MS, helping you plan conversations with your healthcare provider, and directing you to services and support available.

Biogen Support Services offers free access to Nurse Educators 24/7. To reach one, call 1-800-456-2255. Support is also available in Spanish.