VUMERITY Serious
side effects

Allergic reactions (such as welts, hives, swelling of the face, lips, mouth or tongue, or difficulty breathing).

Progressive multifocal leukoencephalopathy (PML) is a rare brain infection that usually leads to death or severe disability over a period of weeks or months. Tell your healthcare provider right away if you get any of these symptoms of PML:

• weakness on one side of the body that gets worse
• clumsiness in your arms or legs
• vision problems
• changes in thinking and memory
• confusion
• personality changes

Herpes zoster infections (commonly known as shingles), including infections of the central nervous system.

Your healthcare provider should check your white blood cell count before you start VUMERITY, 6 months after starting treatment, and then every 6-12 months thereafter as they feel necessary.

Your healthcare provider should do blood tests to check your liver function before you start taking VUMERITY and during treatment if needed. Tell your healthcare provider right away if you get any symptoms of a liver problem during treatment, including:

• severe tiredness
• loss of appetite
• pain on the right side of your stomach
• dark or brown (tea color) urine
• yellowing of your skin or the white part of your eyes

Your healthcare provider should do a blood test before you start treatment with VUMERITY and while you’re on therapy.

Serious gastrointestinal problems include bleeding, ulcers, blockage, and tears (perforations) of the stomach or intestines. Tell your healthcare provider right away if you have any of these symptoms during treatment:

• stomach-area pain that does not go away
• bright red or black stools (that look like tar)
• severe vomiting
• severe diarrhea
• coughing up blood or blood clots
• vomiting blood or vomit that looks like “coffee grounds”